The answer to the question of whether it is safe to do business in the Middle East is, on the whole, yes.
Rates of crime in the Middle East are lower than they are elsewhere, particularly violent crime. So, for example, I would feel much safer walking around a city like Abu Dhabi on my own at 2:00 am compared to a city like London or New York or even Sydney.
Of course, there are exceptions to this rule. As you know, there are countries that are undergoing serious civil unrest in the Middle East and you need to consider carefully before you travel there. It is a good idea to keep your eye on DFAT travel advisories, to watch the news and to talk to colleagues in-country, so that you can get an accurate sense of what is going on and how safe it is to go there. However, generally speaking, in most times and in most places, you have nothing to worry about when it comes to safety and working in or travelling to the Middle East.